Imunopatogeneza Rekurentne Genitalne Kandidoze Kod :lena Immunopathogenesis of Recurrent Genital Candidosis in Women
نویسندگان
چکیده
objasnjavaju u vezi sa ovom vrstom roda Candida [26]. Prvu kariku u patogenetskom lancu cini vezivanje-adherencija C albicans za epitelne celije mukoznih membrana. Najbitniji mehanizam koji uslovIjava adherenciju C albicans za epitelne celije je interakcija izmedu glikoproteina-manana, na povrsini celije mikroorganizma, sa receptorima-proteinorn fibronektrinom na epitelnim celijama [27]. Manan-glikoprotein koji ucestvuje u adherenciji Calbicans, moze da pokrene i alternativni put vezivanja komplementa. Postoje dokazi da C, receptor komponenti sistema komplementa moze imati part icipirajucu ulogu u procesu adherencije. Pretpostavka je da antigenska mimikrija (koja nastaje pri prelasku gljiva u micelijumsku formu) u ispoljavanju .C3 i C2 re?eptora n~ celijskom zidu (do dan as su OVI recepton utvrdeni sarno kod vrste C albicans) moze da ima posledicu izbegavanje dejstva fagocitnih celija domacina, Nairne, C3 receptor moze da vezuje C3 komponentu komplementa, odnosno C,b fragment, pri cemu se C'b fragment preorijentise za vezivanje sa mikroorganizrnorn, a ne sa receptorskim mestima na fagocitu, sto uslovljava rernecenje irnunoloske opsonizacije i fagocitoze [28-30]. Sledeca zbivanja u toku infekcije mukoza vrstom C albicans obuhvataju germinaciju gljiva, stvaranje forme koja omogucava penetraciju uzrocnika u tkiva. Invaziju tkiva potpornazu i kisela proteinaza i fosfolipaza, enzimi koje C albicans produkuje [27, 31].
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